| 产品详情 |
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| Product Name | NSC 405020 |
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| Description | NSC-405020 is a membrane type-I matrix metalloproteinase (MT1-MMP) inhibitor that specifically targets the hemopexin (PEX) domain rather than the catalytic domain of MT1-MMP (IC50 >100 µmol/L). It does not inhibit the catalytic activity of MT1-MMP or MMP-2. NSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. MW: 260.16. Purity ≥98% by HPLC |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3,4-Dichloro-N-(1-methylbutyl)benzamide |
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| Gene, Accession, CAS # | CAS: 7497-07-6 |
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| Catalog # | 2682-25 |
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| Order / More Info | NSC 405020 from BIOVISION, INC. |
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| Product Specific References | n/a |
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