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| Product Name | PNP, aa1-289, Recombinant, Human (Purine Nucleoside Phosphorylase, Inosine Phosphorylase, NP) |
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| Description | Purity ~95% (SDS-PAGE). Purine Nucleoside Phosphorylase (PNP) catalyzes the phophorolysis of N-ribosidic bonds of purine nucleosides and deoxynucleosides. Physiological substrates of PNP include inosine, guanosine, and 2'-deoxyguanosine, but not adenosine (1). PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised T-lymphocyte function and neurologic dysfunction (2, 3). PNP is used in assays for the measurement of inorganic phosphate (4). Source: Recombinant corresponding to aa1-289 from human PNP, fused with 6-His tag at C-terminal, expressed in E. coli. Molecular Weight: ~33kD Endotoxin Level: ≤1EU/1ug (LAL) Biological Activity: Measured by the phosphorolysis of 7-methyl-6-thioguanosine. The specific activity is >35,000 pmoles/min/ug, as measured under the described conditions. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: P00491 |
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| Catalog # | P4350-10A |
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| Order / More Info | PNP, aa1-289, Recombinant, Human (Purine Nucleoside Phosphorylase, Inosine Phosphorylase, NP) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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