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| Product Name | NPM1-ALK Mutant (F1174L), Active |
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| Description | 1-117 (NPM1) 1058-end (F1174L) (ALK). MW: ~108 kDa. Description: Recombinant human fusion protein NPM1 (1-117)-ALK (F1174L) (1058-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: NPM1-ALK which belongs to the insulin receptor superfamily which comprises an extracellular domain, a hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. CD246 plays an important role in the development o |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay |
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| Other Names | [Human nucleophosmin-anaplastic lymphoma kinase fusion protein (NPM/ALK) mRNA, complete cds] |
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| Gene, Accession, CAS # | NPM1-ALK, Accession: U04946.1 |
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| Catalog # | MBS515450 |
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| Order / More Info | NPM1-ALK Mutant (F1174L), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Benharroch, D.et.al: ALK-positive lymphoma: a single disease with a broad spectrum of morphology. Blood 91: 2076-2084, 1998. 2. Zhang, Q. et.al: STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression. |
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