| 产品详情 |
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| Antigenic Specificity | DDIT4 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Western Blot: 2-4 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DDIT4 Polyclonal Antibody. RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis. |
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| Immunogen | n/a |
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| Other Names | Dig2, REDD-1, REDD1, RP11-442H21.1, RTP801; DNA damage-inducible transcript 4 protein; HIF-1 responsive RTP801 (RTP801); HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1 |
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| Gene, Accession # | Entrez: 140942, 54541, 74747; Uniprot: Q8VHZ9, Q9D3F7, Q9NX09 |
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| Catalog # | PA5-20496 |
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| Price | |
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| Order / More Info | DDIT4 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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