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| Product Name | GSK-4112 |
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| Description | GSK-4112 is a selective agonist for REV-ERBα (EC50 = 0.4 µM). At 10 µM, GSK-4112 can reset the circadian rhythm in a phasic manner by inhibiting expression of the circadian target gene bmal1 and reduce glucose output by 30% in mouse primary hepatocytes by repressing the expression of several gluconeogenic genes. GSK-4112 is useful as a chemical tool to probe the function of REV-ERbα in transcriptional repression, regulation of circadian biology, and metabolic pathways. MW: 396.89. Purity ≥98% |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate; SR 6452 |
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| Gene, Accession, CAS # | CAS: 1216744-19-2 |
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| Catalog # | 9663-25 |
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| Order / More Info | GSK-4112 from BIOVISION, INC. |
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| Product Specific References | n/a |
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