| 产品详情 |
| Edit |   |
|---|
| Product Name | GSK126 |
|---|
| Description | A selective, SAM-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM); inhibits global H3K27me3 levels, inhibiting the proliferation of EZH2 mutant DLBCL cell lines (IC50 = 28-61 nM) as well as the growth of EZH2 mutant DLBCL xenografts in mice receiving a daily dose of 50 mg/kg |
|---|
| Size | 1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | histone H3-lysine H3 H3K27 methyltransferase EZH2 inhibitor inhibit HMT cancer GSK-126 S-adenosyl-methionine SAM S-adenosyl methionine S-adenosylmethionine trimethylation trimethylate PRC2 PRC-2 gene DLBCL xenografts chromatin research epigenetic modification KMT6 |
|---|
| Gene, Accession, CAS # | CAS: 1346574-57-9 |
|---|
| Catalog # | 15415-1 |
|---|
| Price | |
|---|
| Order / More Info | GSK126 from CAYMAN CHEMICAL COMPANY |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|