| 产品详情 |
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| Antigenic Specificity | MBD1 |
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| Clone | 7A3C12A9 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ELISA |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-MBD1. MBD1 (Methyl-CpG-binding domain protein 1) is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position five in the cytosine within CpG dinucleotides. At the presence of 7-mG, which is produced by DNA damage from methylmethanesulfonate (MMS), the binding is abolished. MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as histone methyltransferase SETDB1. It probably forms a complex with SETDB1 and ATF7IP that also represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters. |
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| Immunogen | Recombinant fragment |
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| Other Names | MBD1, Methyl-CpG-binding protein MBD1, W0039 |
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| Gene, Accession # | Gene ID: 17190 |
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| Catalog # | 669202 |
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| Price | |
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| Order / More Info | MBD1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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