| 产品详情 |
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| Antigenic Specificity | MBD1 |
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| Clone | FQS4675 |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ICC/IF, IHC-P, IP, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Rabbit Anti-Human MBD1 monoclonal antibody for ICC/IF, IHC-P, IP, WB. Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone Lys-9 trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. |
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| Immunogen | Synthetic peptide |
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| Other Names | n/a |
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| Gene, Accession # | Gene ID: 4152, UniProt: A8K654 |
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| Catalog # | CABT-BL2329 |
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| Price | |
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| Order / More Info | MBD1 Antibody from CREATIVE DIAGNOSTICS |
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| Product Specific References | n/a |
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| 产品资料 |
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