| 产品详情 |
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| Antigenic Specificity | PEN2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PEN2 Polyclonal Antibody. Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. |
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| Immunogen | n/a |
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| Other Names | MDS033, MSTP064, PEN-2, PEN2, gamma-secretase subunit PEN-2, hematopoietic stem/progenitor cells protein MDS033 |
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| Gene, Accession # | Entrez: 55851, 66340; Uniprot: Q9CQR7, Q9NZ42 |
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| Catalog # | 36-7100 |
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| Price | |
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| Order / More Info | PEN2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 16449647, 21253592, 21280074, 22496554, 22511769, 23843529, 25429133, 26581893, 28383037, 29215028 |
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