| 产品详情 |
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| Antigenic Specificity | O6-Methylguanine-DNA-Methyltransferase (MGMT) |
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| Clone | MT3-1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | Protein G purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible, hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.Synonyms: 6-O-methylguanine-DNA methyltransferase, Methylated-DNA-protein-cysteine methyltransferase, O-6-methylguanine-DNA-alkyltransferase |
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| Immunogen | Purified recombinant human MGMT protein. |
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| Other Names | AGT|AI267024|Agat |
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| Gene, Accession # | Gene ID: 4255 |
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| Catalog # | ABIN180357 |
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| Price | |
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| Order / More Info | O6-Methylguanine-DNA-Methyltransferase (MGMT) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 1423289, 7511991, 9062396, 8625442 |
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