| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | HACE1 |
|---|
| Clone | 8D3 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1, kappa |
|---|
| Format | biotin conjugate |
|---|
| Size | 100 ug |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA: Assay Dependent, Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent, Western Blot: Assay Dependent |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | HACE1 Monoclonal Antibody (8D3), Biotin. E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. |
|---|
| Immunogen | n/a |
|---|
| Other Names | E3 ubiquitin-protein ligase HACE1, KIAA1320 |
|---|
| Gene, Accession # | Entrez: 57531; Uniprot: Q8IYU2 |
|---|
| Catalog # | MA5-17702 |
|---|
| Price | |
|---|
| Order / More Info | HACE1 Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|