| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | LIN28A |
|---|
| Clone | 14E6-4E6 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | IgG2a |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | ChIP assay: 1-3 µL, Flow Cytometry: 1:100, Immunocytochemistry: 1:50-1:200, Immunofluorescence: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Immunoprecipitation: 5 µg, Western Blot: 1:1000 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | LIN28A Monoclonal Antibody (14E6-4E6). LIN28A/B are expressed in various cancers and ES cells. LIN28 is a cytoplasmic protein, that acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. LIN28 is a negative regulator of microRNA (miRNA) biogenesis by specifically binding the precursor of let-7 (pre-let-7). Let-7 miRNAs have been implicated in repression of oncogenes such as ras and myc. LIN28 expression decreases during differentiation of ES cells or upon induction of neuronal differentiation by retinoic acid. |
|---|
| Immunogen | n/a |
|---|
| Other Names | Lin-28 homolog A (C. elegans), RNA-binding protein LIN-28, LIN28A, CSDD1, Zinc finger CCHC domain-containing protein 1, ZCCHC1 |
|---|
| Gene, Accession # | Entrez: 79727, 83557; Uniprot: Q8K3Y3, Q9H9Z2 |
|---|
| Catalog # | MA1-016 |
|---|
| Price | |
|---|
| Order / More Info | LIN28A Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | PubMed: 26352799 |
|---|
| 产品资料 |
|
|