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| Antigenic Specificity | Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pSer2448) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC),Immunocytochemistry (ICC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.Synonyms: MTOR, FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 |
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| Immunogen | A phospho specific peptide corresponding to residues surrounding pSer2448 of human mTOR/FRAP |
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| Other Names | FRAP1|FRAP|FRAP2|RAFT1|RAPT1|2610315D21Rik|AI327068|Frap1|flat|frap1|tor|wu:fc22h08 |
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| Gene, Accession # | Gene ID: 2475 |
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| Catalog # | ABIN1513366 |
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| Price | |
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| Order / More Info | Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pSer2448) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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