| 产品详情 |
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| Product Name | CCT196969 |
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| Description | A multi-kinase inhibitor; inhibits B-RAF, B-RAFV600E, C-RAF, Src, and LCK (IC50s = 100, 40, 12, 26, and 14 nM, respectively); only inhibits RAFs, Src, LCK, and MAPKs in a panel of 63 kinases at 1 µM; inhibits MEK and ERK signaling in B-RAF mutant WM266.4 cells; inhibits growth of B-RAF mutant melanoma cells; induces tumor regression in a B-RAF mutant A375 mouse xenograft model at 20 mg/kg per day; inhibits ERK and Src signaling and induces tumor regression in B-RAF inhibitor-resistant PDX mouse models |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CCT-196969 BRAF V600E CRAF WM-266.4 D-35 A-375 |
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| Gene, Accession, CAS # | CAS: 1163719-56-9 |
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| Catalog # | 25537-1 |
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| Order / More Info | CCT196969 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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