| 产品详情 |
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| Product Name | NT-157 |
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| Description | An allosteric inhibitor of IGF-1R signaling; binding induces detachment of IRS1/2, recruitment of Shc to IGF-1R, and inhibitory phosphorylation and degradation of IRS1/2 in a MAPK-dependent manner; induces phosphorylation of IRS1/2 and cell death in 451-Lu-BR and MEL1617-BR melanoma cells; reduces tumor volume in a 451-Lu-BR mouse xenograft model (20 and 50 mg/kg); delays tumor progression in an LNCaP mouse xenograft model; reduces tumor growth when administered alone and does so synergistically when administered with docetaxel in a PC3 mouse xenograft model; reduces severity of bone erosions in a mouse model of arthritis induced by mBSA (10 mg/kg) |
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| Size | 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Tyrphostin NT-157 |
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| Gene, Accession, CAS # | CAS: 1384426-12-3 |
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| Catalog # | 23442-25 |
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| Price | |
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| Order / More Info | NT-157 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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