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| Product Name | Rb Recombinant protein |
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| Description | 48-378. MW: ~62 kDa. Recombinant human Rb (48-378) was expressed in E. coli cells using an N-terminal GST tag.Scientific Background: Rb is the retinoblastoma gene product and was the first tumor suppressor cloned. Rb is a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase (1). Rb can bind to MDM2 and this overcomes both the antiapoptotic function of MDM2 and the MDM2-dependent degrad |
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| Size | 0.02 mg, 0.05 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay, Western Blot (WB) |
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| Other Names | [RB1; OSRC; pRb; pp110; p105-Rb; Retinoblastoma 1 ; Rb Protein] |
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| Gene, Accession, CAS # | Rb, Gene ID: 5925, Accession: NP_000312.2 |
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| Catalog # | MBS515166 |
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| Order / More Info | Rb Recombinant protein from MYBIOSOURCE INC. |
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| Product Specific References | 1. Hanahan, D.et al: The hallmarks of cancer. Cell 100: 57-70, 2000. 2. Dahiya, A. et al: Linking the Rb and Polycomb pathways. Molec. Cell 8: 557-568, 2001. |
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