| 产品详情 |
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| Antigenic Specificity | EFCAB4B |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 50 µl |
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| Concentration | lyophilized |
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| Applications | Western Blot: 1:400 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | EFCAB4B Polyclonal Antibody. CRACR2A is a Ca(2+)-binding protein that plays a key role in store-operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. CRACR2A acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. Further, CRACR2A regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, CRACR2A dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. |
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| Immunogen | n/a |
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| Other Names | CRAC Channel Regulator 2A |
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| Gene, Accession # | Entrez: 500324, 84766; Uniprot: Q9BSW2 |
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| Catalog # | PA5-77366 |
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| Price | |
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| Order / More Info | EFCAB4B Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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| 产品资料 |
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