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| Product Name | Recombinant Human RB1-inducible coiled-coil protein 1 (RB1CC1), partial |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 47.7kDa. Partial: 1241-1594aa. N-terminal 10xHis-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | FAK family kinase-interacting protein of 200 kDa (FIP200) (KIAA0203) (RBICC) |
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| Gene, Accession, CAS # | RB1CC1, UniProt: Q8TDY2 |
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| Catalog # | RPC26074 |
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| Order / More Info | Recombinant Human RB1-inducible coiled-coil protein 1 (RB1CC1), partial from BIOMATIK |
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| Product Specific References | n/a |
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