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| Product Name | L-168,049 |
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| Description | Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo. Purity 99%. MW (observed): 467.79 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine |
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| Gene, Accession, CAS # | CAS: 191034-25-0 |
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| Catalog # | 2311/10 |
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| Price | |
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| Order / More Info | L-168,049 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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