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| Product Name | Siomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin) |
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| Description | Purity > 95% by HPLC. Siomycin is a macrocyclic antibiotic with potent and selective antibacterial activity discovered in 1969. Recently, siomycin was discovered to be a potent inhibitor of the oncogenic transcription factor-forkhead box M1, FoxM1 (previously known as HFH-11B, Trident, WIN or MPP2). The reduced transcription activity was reflected in the down regulation of protein and mRNA levels of FoxM1 and effects on down stream genes - Cdc25B, Survivin and CENPB. In vitro, siomycin was demonstrated to inhibit FoxM1 induced cell growth on soft agar and selectively kill transformed but not normal cells. |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | S1013-86W |
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| Order / More Info | Siomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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