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| Product Name | SETD8 Recombinant protein |
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| Description | MW: ~68 kDa. Recombinant full-length human SETD8 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: SETD8 or SET domain containing lysine methyltransferase 8 is a lysine methyltransferase that monomethylates p53 in human cell lines. The monomethylation by SETD8 suppresses p53-mediated transcriptional activation of highly responsive target genes, such as p21 (CDKN1A) and PUMA (BBC3) but it has little influence on weak p53 targets (1) |
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| Size | 0.02 mg, 0.05 mg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Other Names | [PR-Set7; SET07; SET8] |
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| Gene, Accession, CAS # | SETD8, Gene ID: 387893, Accession: BC050346 |
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| Catalog # | MBS515135 |
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| Order / More Info | SETD8 Recombinant protein from MYBIOSOURCE INC. |
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| Product Specific References | 1. Shi, X. et al: Modulation of p53 function by SET8-mediated methylation at lysine 382. Molec. Cell 27: 636-646, 2007. 2. Li, Z. et al: Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3116-23. |
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