| 产品详情 |
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| Product Name | Recombinant Sudan ebolavirus Envelope glycoprotein (GP), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 19.4kDa. Partial: 502-637aa. N-terminal 6xHis-tagged. Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus). GP1 is responsible for binding to the receptor (s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. Binding to CD209 and CLEC4M, which are respectively found on dendritic cells (DCs), and on endothelial cells of liver sinusoids and lymph node sinuses, facilitate infection of macrophages and endothelial cells. These interactions not only facilitate virus cell entry, but also allow capture of viral particles by DCs and subsequent transmission to susceptible cells without DCs infection (trans infection). Binding to the macrophage specific lectin CLEC10A also seems to enhance virus infectivity. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | GP1,2; GP |
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| Gene, Accession, CAS # | GP, UniProt: Q7T9D9 |
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| Catalog # | RPC23882 |
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| Price | |
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| Order / More Info | Recombinant Sudan ebolavirus Envelope glycoprotein (GP), partial from BIOMATIK |
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| Product Specific References | n/a |
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