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| Product Name | LY2109761 |
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| Description | Purity >98%. LY2157299 is a small molecule inhibitor of the TGF-Beta receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-Beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 µM of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline |
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| Gene, Accession, CAS # | CAS: 700874-71-1 |
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| Catalog # | LS-H8550 |
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| Order / More Info | LY2109761 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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