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| Product Name | Recombinant Rat Toll-like receptor 4 (Tlr4), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 90.2kDa. Extracellular Domain: 26-638aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Rattus norvegicus (Rat). Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CD_antigen: CD284 |
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| Gene, Accession, CAS # | Tlr4, UniProt: Q9QX05 |
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| Catalog # | RPC20761 |
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| Order / More Info | Recombinant Rat Toll-like receptor 4 (Tlr4), partial from BIOMATIK |
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| Product Specific References | n/a |
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