| 产品详情 |
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| Product Name | SB 203580 Free Base |
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| Description | Purity ≥99% (HPLC, TLC). Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. 2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis. Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364: 229-233 (1995). Hazzalin, C.A., et al. Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene 15: 2321-2331 (1997). Solubility: Soluble in DMSO at 100mg/ml; soluble in ethanol at 12.5mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility. |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole; SAPK2, p38 Inhibitor; Stress-activated Protein Kinase 2 Inhibitor |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | S0096-26A |
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| Price | |
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| Order / More Info | SB 203580 Free Base from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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