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| Antigenic Specificity | Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) |
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| Clone | 1D11 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunoprecipitation (IP),Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD314, also known as NKG2D (natural killer receptor G2D) or KLRK1 (killer cell lectin-like receptor subfamily K, member 1), is a homodimeric C-type lectin-like activating receptor and costimulator with type II membrane orientation (C teminus extracellular). CD314 homodimers are associated with DAP10, a membrane adaptor protein that signals similar to CD28 by recruitment of phosphatidylinositol 3-kinase. Engagement of CD314 amplifies antigen-specific T cell responses in CD314-positive T cell populations. In NK cells, CD314 is a primary activating receptor. As CD314 ligands the MHC class-I chain-related proteins A and B (MICA, MICB) and UL16-binding proteins (ULBPs) have been identified. |
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| Immunogen | NKL cell line |
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| Other Names | KLRK1|NKG2D|CD314|D12S2489E|KLR|NKG2-D|D6H12S2489E|Nkg2d|Nkrp2 |
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| Gene, Accession # | Gene ID: 22914 |
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| Catalog # | ABIN1027687 |
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| Price | |
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| Order / More Info | Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 19952356, 16547270, 18226015, 18469328, 12133944, 11015446, 10426993 |
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