| 产品详情 |
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| Product Name | CX-5461 |
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| Description | CX-5461 is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 µM). At 50 mg/kg, CX-5461 demonstrates in vivo antitumor activity against human solid tumors in mouse xenograft models. MW: 513.61. Purity ≥98% by HPLC |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-(4-methyl-1,4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide |
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| Gene, Accession, CAS # | CAS: 1138549-36-6 |
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| Catalog # | B2183-1 |
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| Price | |
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| Order / More Info | CX-5461 from BIOVISION, INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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