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| Product Name | Recombinant Human Clusterin (CLU) |
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| Description | Purity > 85% as determined by SDS-PAGE. MW: 70.1kDa. Full Length of Mature Protein: 23-449aa. N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged. Homo sapiens (Human). Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Aging-associated gene 4 protein; Apolipoprotein J |
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| Gene, Accession, CAS # | CLU, UniProt: P10909 |
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| Catalog # | RPC21110 |
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| Order / More Info | Recombinant Human Clusterin (CLU) from BIOMATIK |
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| Product Specific References | n/a |
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