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| Product Name | Human CellExp™ Noggin, Human Recombinant |
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| Description | Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. MW: 65 kDa, homodim |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | SYM1, SYNS1, NOG. |
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| Gene, Accession, CAS # | NOG, Gene ID: 9241, Accession: Q13253 |
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| Catalog # | 6474-10 |
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| Order / More Info | Human CellExp™ Noggin, Human Recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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