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| Product Name | Human CellExp™ OX40 Ligand / TNFSF4, Mouse Recombinant |
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| Description | Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1 |
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| Gene, Accession, CAS # | Tnfsf4, Gene ID: 22164, Accession: P43488 |
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| Catalog # | P1232-10 |
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| Order / More Info | Human CellExp™ OX40 Ligand / TNFSF4, Mouse Recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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