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| Product Name | Lens culinaris Agglutinin (LCA) (Agarose) |
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| Description | Lens culinaris agglutinin has a molecular weight of ~49kD and is composed of four subunits-two of ~17,kD and two of 8kD. The isoelectric point of LCA is ~pH 8.5. LCA recognizes sequences containing a-linked mannose residues. Like other mannose specific lectins, divalent cations such as calcium and manganese are required for sugar binding activity. By recognizing additional sugars as part of the receptor structure, LCA has a narrower specificity than Con A. For example, an a-linked fucose residue attached to the N-acetylchitobiose portion of the core oligosaccharide markedly enhances affinity. By exploiting this narrower specificity, glycoproteins and glycopeptides can be subfractionated with LCA after initial isolation with Con A. LCA has been employed to separate lymphocyte populations, as a potent T-cell mitogen, and as one of the most effective agents in preventing skin allograft rejection in model systems. LCA is also used to purify numerous glycoproteins (including immunoglobulins |
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| Size | 2ml, 5ml, 10ml |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | Lentil |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | L1665-15A |
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| Order / More Info | Lens culinaris Agglutinin (LCA) (Agarose) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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