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| Product Name | Recombinant Mouse Interferon regulatory factor 8 |
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| Description | 1-424aa; Full Length. MW: 64.21kD. Purity >90% as determined by SDS-PAGE. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followe |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Interferon consensus sequence-binding protein; ICSBP] |
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| Gene, Accession, CAS # | Irf8, Gene ID: 15900, Accession: NP_001288740.1 |
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| Catalog # | MBS950244 |
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| Order / More Info | Recombinant Mouse Interferon regulatory factor 8 from MYBIOSOURCE INC. |
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| Product Specific References | An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.Driggers P.H., Ennist D.L., Gleason S.L., Mak W.-H., Marks M.S., Levi B.-Z., Flanagan J.R., Appella E., Ozato K.Proc. Natl. Acad. Sci. U.S.A. 87:3743-3747(1990) Autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages.Kong H.J., Anderson D.E., Lee C.H., Jang M.K., Tamura T., Tailor P., Ch |
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