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| Product Name | CD154 CD8a, Fusion Protein (Preservative Free) |
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| Description | Purified by affinity chromatography. Human CD154 (CD40 Ligand) is a member of the tumor necrosis factor (TNF) family and is expressed on the surface of activated T cells. Interaction of CD154 and CD40 is essential for isotype switching in B cells. Known genetic defects that alter this interaction lead to impaired immune system function (1). CD154 has been shown to be hyperexpressed by B and T cells in SLE patients (4). CD154 has been reported to be expressed on vascular endothelial cells, smooth muscle cells and macrophages indicating a possible role for the CD40-CD154 immunoregulatory signaling mechanism during inflammation and immunity in atherogenesis (6). Functional Application: Human CD154-muCD8 binds to cell surface expressed human CD40 and this binding is blocked by anti-human CD154 monoclonal antibody. Human CD154 (CD40 Ligand) muCD8 Fusion Protein* Molecular Structure: A soluble fusion protein consisting of the extracellular domain (213aa) of human CD154 fused to the extracell |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA FC WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C2548-84N7 |
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| Order / More Info | CD154 CD8a, Fusion Protein (Preservative Free) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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