| 产品详情 |
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| Product Name | Cadherin 11, Recombinant, Mouse, Fc Chimera |
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| Description | Purity ~90% (SDS-PAGE). Cadherin-11, also known as OB-Cadherin, is a 120kD member of the classical Cadherin family of calcium-dependent homophilic adhesion proteins. Cadherins are involved in multiple processes including embryonic development, cell migration, and maintenance of epithelial integrity. Cadherin-11 is expressed in embryonic mesodermal tissues and contributes to the morphogenesis of the nervous and skeletal systems. It is expressed on osteoblasts in the adult where it promotes the differentiation of both osteoblasts and chondrocytes. Cadherin-11 is up-regulated on breast cancer and prostate cancer cells which preferentially metastasize to bone. It facilitates this metastasis via homophilic adhesion to bone marrow stroma and osteoblast-expressed Cadherin-11. In the synovium, Cadherin-11 supports adhesion between synoviocytes but promotes cell invasion in synovitis and rheumatoid arthritis. Its up-regulation in the vasculature following injury contributes to intimal hyperplas |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cadherin 11, Recombinant, Mouse, Fc Chimera (Cadherin-11, OSF-4, Osteoblast Cadherin, OB-cadherin, Cdh11, Cad-11) |
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| Gene, Accession, CAS # | SwissProt: P55288 |
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| Catalog # | C0107-06M |
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| Order / More Info | Cadherin 11, Recombinant, Mouse, Fc Chimera from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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