| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human MMP-12 (carrier-free) |
|---|
| Description | Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological and pathological processes such as morphogenesis, differentiation, angiogenesis, tissue remodeling, and tumor invasion. A typical MMP consists of a propeptide of about 80 amino acids, a catalytic metalloproteinase domain of about 170 amino acids, a linker peptide of variable lengths and a hemopexin domain of about 200 amino acids. The zinc binding motif HEXXHXXGXXH in the catalytic domain, and the ‘‘cysteine switch’’ motif PRCGXPD in the propeptide are common structural signatures. MMP-12 (macrophage elastase) is a 54 kDa proenzyme consisted of propeptide, catalytic metalloproteinase domain, and hemopexin domain. The predicted human 54-kD protein is processed by loss of both N- and C-terminal residues to a 22-kD mature form. It is a major proteinase that degrades elastin. MMP-12 can also degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, alpha 1-antitrypsin, and plasminogen. MMP-12 is mainly produced by macrophages and has been shown to be associated with inflammatory skin diseases, atherosclerosis, aneurysms, and cancers. MMP12 can exhibit both proinflammatory and anti-inflammatory activity in a tissue- or disease context-dependent manner. The purified recombinant MMP-12 is consisted of pro-peptide and catalytic domain. |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | BA |
|---|
| Other Names | Macrophage metalloelastase (MME); Matrix metalloproteinase 12 |
|---|
| Gene, Accession, CAS # | Gene ID: 4321 |
|---|
| Catalog # | 764206 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human MMP-12 (carrier-free) from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|