| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Left-Right Determination Factor (LEFTY-A) |
|---|
| Clone | 7C5G1H6H10 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG |
|---|
| Format | unconjugated |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),ELISA,Immunohistochemistry (IHC),Immunoprecipitation (IP),Radioimmunoassay (RIA) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity. |
|---|
| Immunogen | A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY. Immunogentype:Recombinant |
|---|
| Other Names | Left-right determination factor 2 , Protein lefty-2 , Left-right determination factor A , Protein lefty-A , Transforming growth factor beta-4 , TGF-beta-4 ,Endometrial bleeding-associated factor |
|---|
| Gene, Accession # | Gene ID: 7044 |
|---|
| Catalog # | ABIN103459 |
|---|
| Price | |
|---|
| Order / More Info | Left-Right Determination Factor (LEFTY-A) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|