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| Product Name | Recombinant Human TIMP-4 (carrier-free) |
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| Description | Tissue inhibitors of metalloproteinases (TIMPs) are inhibitors of matrix metalloproteinases (MMPs). This family of inhibitors is consisted of four members, TIMP-1, -2, -3 , and -4. Their structures are subdivided into an N-terminal and a C-terminal subdomain. A larger N-terminal domain carries the MMP inhibitory activity and a smaller C-terminal domain mediates other non-inhibitory interactions. Human TIMP-4 is the largest of the currently identified TIMPs. It binds to the hemopexin domatin of pro-MMP-2 as TIMP-2 does and inhibits MT1-MMP with high potency. However, TIMP-4 is unable to promote the activation of pro-MMP-2. Expression of TIMP-4 has been observed in heart, kidney, pancreas, colon, testes, brain and adipose tissue. Elevated levels of TIMP-4 have been found in breast, ovary, cervical, prostate, brain, colon, endometrium, and papillary renal tumors. It has been observed that the TIMP-4 expression has been down regulated epigenetically in failing heart. |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Tissue inhibitor of metalloproteinases 4 |
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| Gene, Accession, CAS # | Gene ID: 7079 |
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| Catalog # | 767506 |
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| Order / More Info | Recombinant Human TIMP-4 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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