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| Product Name | HKI 357 |
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| Description | Potent, irreversible inhibitor of ErbB2 (HER2) and EGFR (IC50 values are 33 and 34 nM respectively). Suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Circumvents mechanisms of resistance to Iressa (Cat. No. 3000) in non-small-cell lung cancer cells. Purity 98%. MW (observed): 574.05 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2E)-N-[[4-[[(3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide |
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| Gene, Accession, CAS # | CAS: 848133-17-5 |
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| Catalog # | 3580/10 |
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| Price | |
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| Order / More Info | HKI 357 from TOCRIS BIOSCIENCE
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| Product Specific References | n/a |
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