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| Product Name | Semagacestat (LY450139) |
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| Description | MW: 361.44. |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS8506425 |
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| Order / More Info | Semagacestat (LY450139) from MYBIOSOURCE INC. |
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| Product Specific References | Semagacestat (LY450139) is a gamma-secretase blocker with an IC50 of 15 nM.beta-amyloid is a peptide of 39 to 43 amino acids. [1] The isoforms with 40 and 42 amino acids (Abeta40/42) are the main constituents of amyloid plaques in the brains of Alzheimer's disease patients. beta-amyloid is formed by proteolysis of APP. Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer's. Semagacestat blocks the enzyme gamma-secretase, w |
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