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| Product Name | Factor XII, Human (Hageman Factor) |
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| Description | Purity ≥95% by SDS-PAGE. purified by immunoaffinity chromatography. Human Factor XII (XII) (Hageman Factor) is a single chain (Mr=78,000) glycoprotein zymogen that circulates in plasma at a concentration of 40 mg/ml (1-5). Reciprical activation of XII to the active serine protease factor XIIa (XIIa) by kallikrein is central to initiation of the intrinsic coagulation pathway. Surface bound a-XIIa in turn activates factor XI to XIa. Secondary cleavage of a-XIIa by kallikrein yields b-XIIa, which catalyzes solution phase activation of kallikrein, factor VII and the classical complement cascade. The ability of a variety of negatively charged substances, both physiological and nonphysiological to promote XII activation and, thus, initiation of the intrinsic pathway has led to the psuedonym ``contact activation''. Binding to anionic surfaces induces a conformational change, making the XII zymogen more susceptible to cleavage by a variety of proteases (6,7). It is unlikely that binding to negat |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F0019-15 |
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| Order / More Info | Factor XII, Human (Hageman Factor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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