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| Product Name | R-Spondin-2, human recombinant |
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| Description | The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation an |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Roof plate-specific Spondin 2, Rspo2 |
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| Gene, Accession, CAS # | RSPO2, Gene ID: 340419, Accession: Q6UXX9 |
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| Catalog # | 7190-10 |
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| Order / More Info | R-Spondin-2, human recombinant from BIOVISION, INC. |
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| Product Specific References | n/a |
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