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| Product Name | Recombinant Mouse N-Cadherin-Fc Chimera (carrier-free) |
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| Description | N-Cadherin (NCAD), also known as Cadherin-2 (CDH2), is a type I membrane protein that preferentially interacts in a homophilic manner. It is a member of the Cadherin super family, a family of calcium dependent cell adhesion molecules. N-Cadherin is primarily expressed in mesenchymal tissues such as neural tissue, retina, endothelial cells, fibroblasts, osteoblasts, mesothelium, myocytes, limb cartilage, oocytes, spermatids, and Sertoli cells. Human N-Cadherin is a 906 amino acid protein with a 25 amino acid signal peptide, a 134 amino acid N-terminal propeptide, a 565 amino acid extracellular domain, a 21 amino acid transmembrane domain, and a 161 amino acid cytoplasmic domain. N-Cadherin shares 98% amino acid sequence identity with both mouse and rat N-Cadherin within the extracellular domain. The N-Cadherin ectodomain can be cleaved by MMP24 which leads to the generation of a soluble 90 kD N-terminal soluble fragment and a 45 kD membrane-bound carboxy-terminal fragment 1. The Carboxy-terminal fragment is further cleaved by gamma-secretase into a 35 kD fragment. MMP24 mediated N-Cadherin cleavage in neural stem cells affects N-Cadherin mediated anchorage of neural stem cells to ependymocytes in the adult, leading to the modulation of neural stem cell quiescence. N-Cadherin is not only involved in cell-cell adhesion, but also in cell differentiation, embryogenesis, migration, invasion and signal transduction. Fibroblast growth factor receptor interaction with N-Cadherin has been implicated in contact-dependent survival of ovarian granulosa cells in a FGFR dependent manner. N-cadherin/FGFR also have a pivotal role in promoting metastasis through differential regulation of ERK and AKT. Due to N-Cadherin's influence on cell migration and invasion, an upregulation of N-Cadherin has been shown to be common amongst aggressive cancer types. N-Cadherin promotes the survival of cancer cells by accelerating migration and invasion of cancer cells. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Cadherin-2, CDH2, Neuronal Cadherin, NCAD, Neuronal Calcium-dependent adhesion protein, CDHN |
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| Gene, Accession, CAS # | Gene ID: 12558 |
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| Catalog # | 778408 |
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| Order / More Info | Recombinant Mouse N-Cadherin-Fc Chimera (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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