| 产品详情 |
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| Product Name | LY354740 |
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| Description | A group II mGluR agonist (Kis = 99 and 94 nM, respectively); inhibits forskolin-stimulated cAMP accumulation in cells expressing human mGluR2 and mGluR3 (EC50s = 5.1 and 24.3 nM, respectively); highly selective for mGluR2 and mGluR3 over mGluR4, mGluR7, mGluR1a, and mGluR5a (EC50s = >100 µM); suppresses electrically stimulated EPSPs in rat striatal neurons in vitro (EC50 = 20 nM); suppresses serotonin-induced EPSCs in rat medial prefrontal cortex in vitro (EC50 = 89.1 nM); attenuates the effects of PCP on working memory, stereotypy, locomotion, and cortical glutamate efflux in a rat model of schizophrenia (10 mg/kg); shows efficacy in animal models of anxiety, epilepsy, and withdrawal from nicotine and morphine |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | LY-354740 Eglumegad Eglumetad mGluR-2 3 4 7 1a 5a |
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| Gene, Accession, CAS # | CAS: 176199-48-7 |
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| Catalog # | 24215-5 |
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| Price | |
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| Order / More Info | LY354740 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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