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| Product Name | Phosphoinositide 3 Kinase, Recombinant, Human, GST-Tag, p110 alpha, p85 alpha (PI3K) |
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| Description | Purity ≥80% by SDS-PAGE. Phosphoinositide 3 Kinase, Recombinant, Bovine, p85 alpha (PI3K) functions as the regulatory subunit of the class IA PI3-kinase isoforms a, b, and d. It contains two SH2 domains that bind to tyrosine-phosphorylated growth factor receptors or substrate adaptor proteins. It also contains a BH (breakpoint cluster region homology) domain that shows GAP activity towards the small GTPases Rab4, Rab5, Cdc42, Rac1 and to a lesser extend towards Rab6 and Rab11. It was shown that PI3Ka catalytic subunit mediated phosphorylation of the p85a adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3'-phosphorylated phosphoinositides. PI3Ka protein kinase activity has been implicated in IRS-1 serine phosphorylation in insulin-treated adipocytes and in STAT3 and IRS-1 phosphorylation upon activation of the type 1 IFN receptor by IFN-a. Complex of N-terminal FLAG-tagged recombinant full-l |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: U79143, XM_043865 |
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| Catalog # | P4073-26C |
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| Order / More Info | Phosphoinositide 3 Kinase, Recombinant, Human, GST-Tag, p110 alpha, p85 alpha (PI3K) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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