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| Product Name | Recombinant Mouse C-X-C motif chemokine 14 protein (Cxcl14) (Active) |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 22.4kDa. Partial: 140-317aa. N-terminal 6xHis-tagged. Homo sapiens (Human). CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-?B (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NF?B, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | CD254; ODF; OPGL; RANK L; TNFSF11; CD254; Osteoclast differentiation factor; Receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11 |
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| Gene, Accession, CAS # | TNFSF11, UniProt: O14788 |
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| Catalog # | RPC26931 |
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| Order / More Info | Recombinant Mouse C-X-C motif chemokine 14 protein (Cxcl14) (Active) from BIOMATIK |
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| Product Specific References | n/a |
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