| 产品详情 |
| Edit |   |
|---|
| Product Name | Sphingosine Kinase Inhibitor IV, CB5468139 |
|---|
| Description | Purity ~98% (HPLC). A cell-permeable naphthoquinone derivative that acts as an ATP-competitive inhibitior against sphingosine kinase 1 (IC50 = 2uM; [sphingosine] = 10uM & [ATP] = 100uM) and several protein kinases, including, but not limited to, TNK2, AURKB, Met, Syk, AURKC, Fyn, Flt2, PIM2, MST2, CLK1, Tie1, and Fak (IC50 <2uM), while exhibiting much reduced potency toward DAG Kinase and sphingosine kinase 2 (37% and no inhibition, respectively, at 100uM). Shown to be more potent than SK1/2 dual inhibitor against kidney adenocarcinoma A498 proliferation (GI50 = 10 and 20uM, respectively; 48h) and the two inhibitors are also reported to induce differential modulations of A498 cellular ceramides and S1P levels when applied at their respective GI50. Formula: C18H18ClNO3 Solubility: DMSO Molar Mass: 331.8 |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Sphingosine Kinase Inhibitor IV, CB5468139 (N-(3-chloro-1,4-dioxo-1,4-dihydro-2-naphthalenyl)-N-cyclohexylacetamide, SK Inhibitor IV, Sphingosine Kinase Inhibitor IV) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217805 |
|---|
| Price | |
|---|
| Order / More Info | Sphingosine Kinase Inhibitor IV, CB5468139 from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|