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| Product Name | Histones |
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| Description | Purified (> 90% pure ). Crude blend of extracted histones that are unfractionated and unpurified. May contain numerous subfractions due to acetylation, methylation and phosphorylation of various amino acid residues. Autoantibodies to histone antigens have been described in patients with idiopathic and drug-induced SLE, rheumatoid arthritis, and other conditions. Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were to H1, H2b, and H3. Marked elevations of binding occurred to H1 and H2b in 33% of patients, while 25% showed higher binding to H3 (2). The same study showed the highest anti-histone reactivity to be in patients with rheumatoid arthritis with vasculitis, while the highest reactivity in SLE sera was in those patients with a history of photosensi |
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| Size | 250mg, 1g |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | H5110-06C |
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| Order / More Info | Histones from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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