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| Product Name | STK3, Active, Recombinant, Human (Serine/Threonine Protein Kinase 3) |
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| Description | Purity ~90% (SDS-PAGE). Creasy identified a cDNA encoding STK3, which they called MST2. Sequence analysis indicated that the deduced 491aa STK3 protein contains an N-terminal catalytic domain characteristic of STKs (1). Taylor also isolated cDNAs encoding STK3 (p63) and STK4 (p61) respectively. STK3 and STK4 share 94% amino acid identity in the catalytic domain and 78% identity overall (2). The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. O'Neill used proteomic analysis of RAF1 signaling complexes to show that RAF1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2) (3). MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (2; 4). STK3 activation presumably allows cells to resist unfavorable environmental conditions. Source: Recombinant protein corresponding to human STK3, expre |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | STK-3, STK 3, Active STK3, STK3, STK, human STK3, active kinase, active kinases, recombinant STK3, recombinant STK, kinase activity assay, protein kinase |
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| Gene, Accession, CAS # | STK3, Gene ID: 6788, SwissProt: Q13188 |
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| Catalog # | 220285 |
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| Order / More Info | STK3, Active, Recombinant, Human (Serine/Threonine Protein Kinase 3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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