| 产品详情 |
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| Product Name | Mycobacterium Bactericide, TCA1 |
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| Description | Purity ~97% (HPLC). A cell-permeable benzothiazolylthiophene that exhibits bactericidal activity against mycobacteria, including M. smegmatis, M. bovis GCG, and M. tuberculosis (MIC50 = 30, 40, and 10ng/mL, respectively, in biofilm medium; MIC50 = 4.5, 3, 0.19ug/mL, respectively, in 7H9 medium), but not E. coli, Staphylococcus aureus, or Pseudomonas aeruginosa, by simultaneously targeting DprE1 FAD-binding domain of DprE1/DprE2 required for Mycobacterium cell wall arabinan biosynthesis and the Mtb MoeW protein involved in the biosynthesis of MoCo, molybdenum cofactor indispensable for nitrate assimilation via MoCo-dependent enzymes. Either alone or used in combination, TCA1 is shown to greatly complement INH (Isoniazid) and RIF (Rifampicin) against both wt and drug-resistant Mtb cultures in vitro (1-7.5ug/mL) and in treating acute and chronic Mtb H37Rv infections in mice in vivo (10-100mg/kg p.o.) with no apparent host toxicity. Primary Target: DprE1 Secondary Target: MoeW Solubility: |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Mycobacterium Bactericide, TCA1 (Ethyl-(2-(benzo[d]thiazole-2-carboxamido)thiophene-3-carbonyl)carbamate, Ethyl-((2-((1,3-benzothiazol-2-ylcarbonyl)amino)-3-thienyl)carbonyl)carbamate, Mtb Inhibitor, Mycobacteria DprE1 Inhibitor, Mycobacteria MoeW Inhibitor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217575 |
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| Price | |
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| Order / More Info | Mycobacterium Bactericide, TCA1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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