| 产品详情 |
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| Antigenic Specificity | CD86 |
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| Clone | PO3 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, κ |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PE anti-mouse CD86. CD86 is an 80 kD immunoglobulin superfamily member, also known as B7-2, B70, and Ly-58. CD86 is expressed on activated B and T cells, macrophages, dendritic cells and astrocytes. CD86 along with CD80 are the ligands of CD28 and CD152 (CTLA-4). CD86 is expressed earlier in the immune response than CD80. CD86 has also been shown to be involved in immunoglobulin class-switching and triggering of NK cell-mediated cytotoxicity. CD86 binds to CD28 to transduce co-stimulatory signals for T cell activation, proliferation, and cytokine production. CD86 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells. The PO3 antibody has been shown to block autoantibody production in vivo and inhibit T cell activation in vitro. |
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| Immunogen | BALB/c mouse B leukemia cell line BCL1 |
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| Other Names | B7-2, B70, Ly-58 |
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| Gene, Accession # | Gene ID: 12524 |
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| Catalog # | 105106 |
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| Price | |
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| Order / More Info | CD86 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 24696476 |
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| 产品资料 |
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